REthinking Clinical Trials



Oral antibiotics (pre-treatment vs no treatment) in colorectal surgery Principal

Principal Investigator(s): Dr. Rebecca Auer NCT03663504
The divergence of clinical practice guidelines, in addition to observation from the large North American retrospective studies, suggest that surgeons and centers have not established a standard of care for the preoperative preparation of the bowel prior to colorectal surgery. Multiple trials have demonstrated that the use of mechanical bowel preparation (MBP) has been associated with no reduction and possibly an increase in surgical infections but that MBP plus oral antibiotics are superior to MBP alone.  In this study, we hypothesize that it is the oral antibiotics, and not the MBP, that is responsible for the reduction in postoperative infectious surgical complications in patients undergoing elective colorectal resections.

Funded by a TOHAMO Innovation grant.

Sites: Hopital Montfort Mount Sinai Cancer Centre Queensway Carleton Hospital The Ottawa Hospital Toronto Western (UHN)

Tags: Colon cancer Surgery


Study Protocol:

  • Prospective randomised controlled trial using the REthinking Clinical Trials (REaCT) platform and National Surgical Quality Improvement Program (NSQIP) to compare no preparation versus preoperative oral antibiotics alone for surgical site infection rates in elective colon surgery: a protocol. Apte et al, 2020. PMID: 32647023