Affiliated with uOttawa

REaCT
REthinking Clinical Trials

REaCT-RETT

REaCT-RETT

Concurrent radiation + endocrine therapy vs sequential radiation + endrocrine therapy

Principal Investigator(s): Dr. Jean-Marc Bourque and Dr. Sharon McGee

ClinicalTrials.gov: NCT03948568
After breast cancer surgery, patients receive either concurrent or sequential endocrine and radiation therapy, where concurrent therapy consists of endocrine therapy started before, with or during radiotherapy, while sequential treatment is defined as endocrine therapy starting after the completion of radiotherapy. This randomized clinical trial investigating the timing of adjuvant radiation and endocrine therapy in patients with early-stage breast cancer. Although these are established treatments received by a large proportion of breast cancer patients, the optimal timing remains unclear. This trial is comparing endocrine therapy given alongside, or following completion of, adjuvant radiotherapy, with key endpoints being endocrine therapy tolerance, and compliance.

Sites: Lakeridge Health (Oshawa) Markham Stouffville Hospital The Ottawa Hospital

Tags: Early stage Breast Cancer

Publications:

Systematic Review:

  • Optimal sequence of adjuvant endocrine and radiation therapy in early-stage breast cancer – A systematic review. McGee et al, 2019. PMID: 30014951

Physician Survey:

  • Physician Survey of Timing of Adjuvant Endocrine Therapy Relative to Radiotherapy in Early Stage Breast Cancer Patients. McGee et al, 2019. PMID: 30318304

Clinical Trial results:

  • A randomized trial evaluating endocrine toxicity with concurrent versus sequential radiation and endocrine therapy in early-stage, hormone responsive breast cancer. McGee et al. Under review